Mediastinal Grey Zone Lymphoma
Conditions
Brief summary
Mediastinal grey zone lymphoma, B cell lymphomas with intermediate features between classical Hodgkin lymphoma and primary mediastinal B cell lymphoma, are not well described in the literature. Investigators report the clinical characteristics and outcomes of a large retrospective series of 99 cases centrally reviewed by a panel of hematopathologists, with a consensus established for the diagnosis.
Interventions
None listed
Sponsors
Hospices Civils de Lyon
Study design
Observational model
OTHER
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* cases with an intermediate morphology and phenotype between CHL and PMBCL were included after central pathological review
Exclusion criteria
* Cases of CHL with partial CD20 expression or low expression in tumoral cells were excluded and considered as CD20-positive CHL * Exclusion of sequential form patients (with a diagnostic biopsy of PMBCL and a relapse biopsy of CHL or vise-versa) as they represent a biases for statistical analysis.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| EFS in the global population of GZL | EFS: Event Free Survival from date of randomization until the date of first documented progression, up to 130 months | Event-free survival (EFS) was calculated from the date of diagnosis to the date of progression, a change of therapy that was not initially scheduled (radiotherapy, high-dose therapy with autologous stem cell transplantation and other unplanned treatments) or death from any cause. |
Countries
France
Outcome results
None listed