Hemorrhoids
Conditions
Brief summary
Trimebutine acts through smooth muscle relaxation. It is presumed that the topical application of trimebutine after hemorrhoidectomy may help relieve pain after the procedure by relaxing the internal anal sphincter spasm.
Detailed description
A randomized trial will be carried out to investigate the effect of trimebutine on pain after Milligan-Morgan hemorrhoidectomy. Trimebutine relaxes the internal anal sphincter spasm which usually occurs after excisional hemorrhoidectomy.
Interventions
DRUGTrimebutine
Trimebutine suppository will be inserted in the anal canal on completion of hemorrhoidectomy then at six and 12 hours postoperatively.
PROCEDUREHemorrhoidectomy
Patients will undergo classic Milliagn-Morgan hemorrhoidectomy
Sponsors
Mansoura University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Patients of both genders aging between 18-70 years with grade III/VI internal hemorrhoids will be included
Exclusion criteria
* Patients with grade I/II internal hemorrhoids or external hemorrhoids. * Patients with associated anorectal pathology such as anal fissure, anal fistula, rectal prolapse, neoplasm, solitary rectal ulcer, and inflammatory bowel diseases.\\ * Patients with recurrent hemorrhoids after previous surgery.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain assessment assessed using visual analogue score from 0-10 | Pain will be assessed at 12 hours after the procedure | Anal pain will be assessed using visual analogue score from 0-10 |
Countries
Egypt
Outcome results
None listed