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Gastric Emptying of Rice With Different Starch Properties

Assessment of Gastric Emptying and Fullness of Rice With Different Starch Properties

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03035981
Enrollment
12
Registered
2017-01-30
Start date
2014-08-31
Completion date
2014-12-31
Last updated
2017-01-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Appetitive Behavior

Brief summary

Glycemic carbohydrates are associated with metabolic disturbances, such as type II diabetes, due to rapid digestion of starch into glucose. The specific properties of starch within these foods has been studied for the purpose of slowing their digestion rate and improving related physiological outcomes, such as gastric emptying rate. The current study investigated the relationship among starch digestion, gastric emptying rate and satiety in white and brown rice.

Detailed description

Studies have indicated that starch-based foods with somewhat high amylose content have slower in vitro starch digestion rates, which relate to a low glycemic response. Low glycemic response is associated with delayed gastric emptying rate as well. Therefore, we hypothesized that rice with a slow starch digesting property would delay gastric emptying. White and brown rice with varying amylose contents were used in this study. A 13C-labeled octanoic acid breath test method was used to measure gastric emptying rate, and questionnaires were used to assess hunger and fullness during the testing sessions. Twelve healthy volunteers were recruited to participate in a crossover design study with six rice treatments and outcome measurements were gastric emptying and satiety assessments. One fermentable carbohydrate (fructooligosaccharide, FOS) solution was used to validate the production of breath hydrogen.

Interventions

OTHERWhite rice, low amylose

White and brown rice were tested for differences in gastric emptying rate and appetitive response

OTHERWhite rice, high amylose

White and brown rice were tested for differences in gastric emptying rate and appetitive response

OTHERWhite rice, slow

White and brown rice were tested for differences in gastric emptying rate and appetitive response

OTHERWhite rice, resistant

White and brown rice were tested for differences in gastric emptying rate and appetitive response

OTHERBrown rice, low amylose

White and brown rice were tested for differences in gastric emptying rate and appetitive response

OTHERBrown rice, high amylose

White and brown rice were tested for differences in gastric emptying rate and appetitive response

OTHERFructooligosaccharide (FOS)

White and brown rice were tested for differences in gastric emptying rate and appetitive response

Sponsors

Purdue University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes

Inclusion criteria

* Normal body mass index (18 kg/m2 ≤ BMI ≤ 25 kg/m2)

Exclusion criteria

* Under any medication * History of any gastrointestinal disease or surgery * Diabetes * Smoker

Design outcomes

Primary

MeasureTime frameDescription
Gastric emptyingAcute study, 4 hours after consumption of test foodBreath test was performed using 13C-octanoic acid mixed into test meals
Appetitive responseAcute study, 4 hours after consumption of test foodFullness and hunger questionnaire was given at various time points after consumption of test foods

Secondary

MeasureTime frameDescription
Breath hydrogenAcute study, 4 hours after consumption of test foodHydrogen breath test was performed following ingestion of test meals

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026