Stroke
Conditions
Brief summary
The purpose of this research study is to determine whether a combined electroencephalography (EEG) and functional near infrared spectroscopy (fNIRS) recording is able to detect changes in brain activity and blood flow after stroke.
Interventions
DEVICECombined EEG and fNIRS
The EEG+NIRS recordings will be obtained via an extended EEG cap that is applied to the subject's head. Changes in neuronal activity and hemodynamics will be measured. The EEG component is the microEEG by BioSignal Group, UA. The fNIRS component is the NIRScout 24x32, NIRx Medizintechnik GmbH, Germany
Sponsors
University of Houston
The University of Texas Health Science Center, Houston
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DEVICE_FEASIBILITY
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All patients with a subacute ischemic stroke with symptom onset within 8 weeks * Must have a measurable deficit on the National Institute of Health Stroke Scale (NIHSS) * Able to give and sign informed consent
Exclusion criteria
* Aphasia * Underlying dementia * Any chronic neurological disorder * Malignancy * Non-ambulatory (ambulation with assistance will be included) * Modified Rankin Score (mRS) \> 3
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants with abnormal blood flow as assessed by fNIRS | immediately at the time of combined EEG and fNIRS for up to 60 minutes | Abnormal blood flow is determined by comparing a part of the patient's brain not affected by stroke to a part of the patient's brain affected by stroke. |
| Number of participants with abnormal neuronal activity as assessed by EEG | immediately at the time of combined EEG and fNIRS for up to 60 minutes | Abnormal neuronal activity is determined by comparing a part of the patient's brain not affected by stroke to a part of the patient's brain affected by stroke. |
Countries
United States
Outcome results
None listed