Healthy
Conditions
Brief summary
The overall goal of this proposed study is to assess the reliability of plasticity measured by transcranial magnetic stimulation (TMS) interleaved with intermittent theta-burst stimulation plasticity measures and to assess the influence of an acute bout of aerobic exercise on TMS plasticity measures.
Interventions
BEHAVIORALShort-term aerobic exercise
One bout of moderate intensity exercise (75% of maximal predicated heart rate).
Sponsors
University of Miami
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Adult males and females aged 18-70 years old. * Primary language is English * Exercise clearance
Exclusion criteria
* Presence of cognitive, neurologic or orthopedic conditions that could affect performance of the testing and training procedures * History of migraines * History of fainting spells of unknown or undetermined etiology that might constitute seizures * History of seizures, diagnosis of epilepsy, history of abnormal (epileptiform) EEG or family history of treatment resistance epilepsy * Any current history of psychiatric illness * Any unstable medical condition * No medication is an absolute exclusion from TMS. Medications will be reviewed by the Principal Investigator and a decision about inclusion will be made based on the following: * The subject's past medical history, drug does, history of recent medication changes or duration of treatment, and combination with other central nervous system active drugs. * The published TMS guidelines review medications to considered with TMS (Rossi, Hallet, Rossini, Pascual-Leone, & Safety of TMS Consensus Group, 2009) * Any metal in the brain, skull or elsewhere unless approved by the responsible MD * Any medical devices (i.e. Cardiac pacemaker, deep brain stimulator, medication infusion pump, cochlear implant, vagal nerve stimulator) * Intracranial lesion * Substance abuse or dependence within the past six months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in cortical synaptic plasticity | Baseline, 1 week | As measured via Transcranial Magnetic Stimulation (TMS) in mean motor evoked potential (MEP) amplitude |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Assess TMS plasticity measures on healthy individuals after an acute bout of exercise | Baseline, 3 weeks | As measured via Transcranial Magnetic Stimulation (TMS) in mean motor evoked potential (MEP) amplitude after an acute bout of aerobic exercise |
Countries
United States
Outcome results
None listed