Conventional Fasting Versus Lipid/Carbohydrate Infusion for Coronary Bypass Patients

Comparative Study Between Conventional Fasting Versus Overnight Infusion of Lipid or Carbohydrate on Free Fatty Acid and Insulin in Obese Patients Undergoing Elective First Time On-pump Coronary Artery Bypass Grafting

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03033667

Enrollment

Registered

2017-01-27

Start date

2014-09-30

Completion date

2016-07-31

Last updated

2017-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Metabolism Disorder

Keywords

perioperative fasting, free fatty acids, coronary bypass grfting

Brief summary

Comparative study between conventional fasting versus overnight infusion of lipid or carbohydrate on free fatty acids and insulin in obese patients undergoing elective first time on-pump coronary artery bypass grafting.

Detailed description

Obese patients scheduled for bypass surgery randomly assigned to three groups: Group I (Glucose-group): patients received 500 cc of glucose 10% containing 50 g of glucose and providing patients with 200 Kcal with an osmolarity of 556 mosm/L. Group II (Lipid-group): patients received 100 cc of lipid solution (soybean 30%, medium chain triglycerides 30%,olive oil 25%,fish oil 15% and 20 mg vitamine E) containing 20 g lipid and provides patients with 200 Kcal with an osmolarity of 380 mosm/L. Group III (Control-group): patients fasted overnight from 11 pm till 9 am except for clear fluids which were allowed till 5 am.

Interventions

DIETARY_SUPPLEMENTG group

patients received 500 cc of glucose 10% containing 50 g of glucose proving patients with 200 Kcal with 556 mosmoles/L

DIETARY_SUPPLEMENTgroup L

patients received 100 cc of lipid solution (soybean 30%, medium chain triglycerides 30%,olive oil 25%,fish oil 15% and 20 mg vitamine E) containing 20 g lipid which provided patients with 200 Kcal with osmolarity of 380 mosmoles /L. with a flow rate of infusion of 12.5 cc per hour

DIETARY_SUPPLEMENTGroup C

Over night fasting with no supplementation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Adult patients (\> 18 years) with American Society of Anesthesia (ASA) class II-III, BMI 30-40, and New York Heart Association (NYHA) functional capacities I-II, undergoing elective on-pump coronary artery bypass grafting (CABG) using cardiopulmonary bypass (CPB). All patients were type 1a World Health Organisation (WHO)/Fredrickson classification of primary hyperlipidemias.

Exclusion criteria

* Patients with diabetes mellitus * Patients on fibrates * Patients type 1,2b,3,4 and 5 WHO/Fredrickson classification of primary hyperperlipidemias * Patients with history of allergic reactions to fish, egg yolk containing foods peanut or soy products * Patients with carbohydrate or fat intolerance

Design outcomes

Primary

Measure	Time frame
The change in free fatty acids levels and insulin blood levels before and after the infusion of study solution	Over an infusion period of 10 hours preoperatively

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026