Right Ventricular Dysfunction Incidence After Major Lung Resection

Right Ventricular Dysfunction Incidence After Major Lung Resection, a Prospective Study.

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03032900

Acronym

RESECHO

Enrollment

110

Registered

2017-01-26

Start date

2017-01-01

Completion date

2018-07-02

Last updated

2018-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major Lung Resection, Right Ventricular Dysfunction

Keywords

Major lung resection, Right Ventricular Dysfunction, 2D Strain

Brief summary

This study aims to describe incidence of right ventricular dysfunction after major lung resection with echocardiography criteria.

Detailed description

Few clinical trial studied the incidence of right ventricular dysfunction after major lung resection and time frame of occurrence. In this prospective observational study the right ventricular function will be mesure with echocardiographic criteria. Echocardiographic exam will be standardised and be realised day before surgery (at the same time that inclusion), day 1, day 2 and day 3 after surgery. In order to assess prognostic value of right dysfunction after lung resection, data as hospitalization stay, complications and survival will be collected at 6 months. Cardiac cycles will be recorded and be analysed by a single observer blind to the clinical finding and other echocardiographic measurements.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Written consent * Patient older than 18 years * Major lung surgery (pneumonectomy, lobectomy)

Exclusion criteria

* Pre-existing pulmonary arteria hypertension * Post-operative surgical complication on day 1 to 3 (bleeding, revision surgery) * Technical difficulty preventing adequate echocardiographic assessment * Patient refusal

Design outcomes

Primary

Measure	Time frame	Description
Right ventricular dysfunction	5 days	Without pre-existing pulmonary arteria hypertension, it will be assess with echocardiography criteria : PAPS \> 35mmHg or right ventricular dilatation or right systolic markers abnormalities.

Secondary

Measure	Time frame	Description
Risk factors	5 days	Determining risk factors for developing right ventricular failure after pulmonary resection
Time frame to right ventricular dysfunction	5 days	Time frame to right ventricular dysfunction
Assessment of 2D strain for right ventricular dysfunctio	5 days	Assessment of 2D strain for right ventricular dysfunction
Estimate impact of right ventricular dysfunction on patient prognosis.	5 days	Estimate impact of right ventricular dysfunction on patient prognosis.

Countries

France

Outcome results