Community Based Screening for Colorectal Cancer in an Underserved High Risk Population in Nigeria

Colorectal Cancer Control in Low Resource Countries: Results From a Prospective Cohort Study of Patients at High-risk for Colorectal Cancer

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03032874

Enrollment

100

Registered

2017-01-26

Start date

2014-01-01

Completion date

2016-07-30

Last updated

2017-01-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal Cancer

Keywords

Colorectal cancer, Polyps, Colonoscopy, Rectal bleeding, Nigeria

Brief summary

Patient age 45 year old and above who presented with rectal bleeding at three tertiary hospitals in South West Nigeria were invited for colonoscopy. The clinical information of the patients and the colonoscopy data were analyzed

Detailed description

Patient age 45 year old and above who presented with rectal bleeding at Obafemi Awolowo University Teaching Hospitals Complex, Ile Ife, Nigeria, University College Hospital, Ibadan, Nigeria, and University of Ilorin Teaching Hospital, Ilorin Nigeria were invited for colonoscopy. Categorical variables were compared using χ2-test or Fisher's exact test while the Kruskal-Wallis test was used for quantitative variables. Multivariate analysis was performed using logistic regression model. All statistical tests were two-sided and p-values below 0.05 were considered statistically significant. Statistical analysis was carried out using SAS 9.4 and R 3.3.1.

Interventions

PROCEDUREColonoscopy

They all had screening colonoscopy

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

45 Years to No maximum

Healthy volunteers

Inclusion criteria

* must be 45-years of age or older * has rectal bleeding lasting at least one week * has had a complete colonoscopy performed

Exclusion criteria

* Individuals with a personal history of inflammatory bowel disease, colorectal polyps, colorectal adenoma or CRC * Individuals with a family history of familial adenomatous polyposis syndromes or other hereditary polyposis syndromes, hereditary nonpolyposis colorectal cancer * Individuals with severe comorbidities that were contraindication to colonoscopy * Individuals who had a previous history of colectomy

Design outcomes

Primary

Measure	Time frame	Description
To determine colonoscopy polyp and cancer detection rate	2 years	The hypothesis for this study was that colonoscopy surveillance of a high-risk cohort of patients with rectal bleeding would demonstrate that 10-20% of these patients have pre-malignant colorectal polyps(adenomas) or cancers.

Secondary

Measure	Time frame	Description
To detect colorectal cancer early using symptoms based assessment	2 years	The long-term impact of identifying at risk patients and patients with early stage cancers may be a reduction in mortality from colorectal cancer in low- and middle- income countries

Countries

Nigeria

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026