Identifying Targets of Maladaptive Metabolic Responses in Heart Failure

Status

Active, not recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03032627

Enrollment

Registered

2017-01-26

Start date

2017-03-20

Completion date

2025-12-31

Last updated

2025-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Failure

Brief summary

The purpose of the research is to help researchers understand changes in metabolism in patients that develop heart failure.

Interventions

PROCEDURECollection of discarded heart tissue

Discarded heart tissue will be collected from patients undergoing the aforementioned cardiac surgeries.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

19 Years to 89 Years

Healthy volunteers

Yes

Inclusion criteria

1. Subjects are capable of giving informed consent. 2. Age 19-89 3. Diagnosis of chronic heart failure 4. Any patients scheduled for at least one of the following procedures: 1. LVAD implantation or as recipient for cardiac transplantation. 2. LVAD placement both as bridge to transplant and as destination therapy. 3. LVAD explantation 4. Valve replacement or repair 5. Catheterization and myocardial biopsy for idiopathic cardiomyopathy 6. Coronary artery bypass graft (CABG)

Exclusion criteria

1. Life expectancy less than 2 weeks 2. Diagnosed with following co-morbidities: cancer, chronic kidney disease (GFR≤30 or serum creatinine \>2.1), active infection or treatment with antibiotics or persistent infectious disease (hepatitis, HIV, etc), cirrhosis, active substance abuse and/or alcohol dependence (≥ 14 alcoholic beverages per week). Control Myocardial Tissue from Donor Hearts Inclusion Criteria 1. Samples collected from non-failing hearts deemed unsuitable for transplantation by TransLife because of either acute recipient issues or post-harvest evidence of pathology or positive but benign serology. 2. Normal cardiac function from medical records

Design outcomes

Primary

Measure	Time frame	Description
Analyses of collected tissues	Restricted to the time around surgical procedure	Tissue samples collected during surgery will be analyzed by way of immunoblot and qrtPCR of mRNA for metabolic enzymes on neutralized acid extracts.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026