Analysis of Body Composition in Relation to Outcome After Surgery in a Cohort of Patients With Esophageal Cancer

Analysis of Sarcopenia and Body Composition in Relation to Outcome in a Cohort of Patients With Esophageal Cancer or Cancer of the Gastroesophageal Junction Before and After Surgery With Curative Intent

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03032224

Enrollment

Registered

2017-01-26

Start date

2015-03-23

Completion date

2020-07-23

Last updated

2020-07-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer of Esophagus, Gastric Cancer

Keywords

Body composition, sarcopenia, Dysphagia, Surgery, Quality of Life, Morbidity

Brief summary

The occurrence of dysphagia is a well-known early feature of esophageal cancer that may reduce caloric intake and thus cause weight loss. Sarcopenia is considered to be a consequence of such involuntary nutritional restriction. The prevalence of sarcopenia in patients with esophageal cancer before and after surgery is not well known and its possible consequences have been debated. Aim: The aim of this study was to prospectively explore body composition and function in a cohort of patients with esophageal cancer before and after surgery with curative intent. In particular, to investigate the prevalence and development of sarcopenia and body composition as a consequence to surgery for esophageal cancer and the possible relation to morbidity, length of stay and quality of life (QoL). Methods: In a cohort of 76 patients who had esophageal- or cardia-cancer and were planned for surgery with a curative intent, data on body-composition measured with bioimpedance, working capacity (cardiac stress test), grip strength and QoL (European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaires (QLQ)-C30 version 3.0) were prospectively collected. Data regarding dysphagia was derived from an esophagus related quality of life form (EORTC QLQ-OES18). Data on tumour stage and type, complications, length of stay and preoperative weight loss were collected from medical charts.

Interventions

PROCEDUREResection of the esophagus and the gastroesophageal junction

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Cancer of the gastro-esophageal junction or the esophagus. * Planned for curative surgery. * Informed consent

Exclusion criteria

* Not fulfilling the above. * Patient declined participation.

Design outcomes

Primary

Measure	Time frame	Description
Changes in Body composition after surgery for esophageal cancer with curative intent.	Three months	Body mass index (BMI) kg/m2
Changes in Body composition after surgery for esophageal cancer with curative intent	Three months	Weight kg

Secondary

Measure	Time frame
Length of stay (days)	From surgery up to three months
Changes in QoL (linear scale 0-100)	From surgery up to three months
Mortality	Length of survival after surgery
Complications after surgery (Clavien-Dindo scale 0-5)	From surgery up to three months
Changes in dysphagia (linear scale 0-100)	From surgery up to three months

Countries

Sweden

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026