Efficacy of Administration of ACE-Inhibition on Autonomic and Peripheral Neuropathy in Patients With Diabetes Mellitus

Efficacy of Administration of Angiotensin Converting Enzyme Inhibition on Autonomic and Peripheral Neuropathy in Patients With Diabetes Mellitus

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03031834

Enrollment

Unknown

Registered

2017-01-26

Start date

1999-01-31

Completion date

Unknown

Last updated

2017-01-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetic Autonomic Neuropathy

Brief summary

Patients with diabetes mellitus and definite autonomic and peripheral neuropathy were randomized to receive quinapril or no treatment for 2 years.

Interventions

DRUGQuinapril

Eligibility

Sex/Gender

ALL

Inclusion criteria

* Diabetes mellitus with both autonomic and peripheral neuropathy

Exclusion criteria

* Hypertension, coronary heart disease

Design outcomes

Primary

Measure	Time frame
Changes in R-R variation during deep breathing	2 years
Changes in response to Valsalva maneuver	2 years
Changes in 30:15 ratio	2 years
Changes in blood pressure response to standing	2 years

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026