Clinical Course of Cirrhotic Patients With Portal Vein Thrombosis Treated With TIPS

Follow-up and Survival of Cirrhotic and Non Cirrhotic Patients With Portal Vein Thrombosis Treated With Transjugular Intrahepatic Portosystemic Shunt

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03031717

Enrollment

Registered

2017-01-26

Start date

2017-01-01

Completion date

2023-06-30

Last updated

2020-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Portal Vein Thrombosis

Brief summary

Portal vein thrombosis (PVT) is defined as an obstruction of the portal vein. The prevalence of PVT is 10-25% and incidence is about 16% in cirrhotic patients. PVT leads to increased intrahepatic resistance, decreased portal velocities, splanchnic vasodilatation, and stagnant flow. Portal vein recanalization (PVR) with transjugular intrahepatic portosystemic shunt (TIPS) is aimed at restoring main portal vein (PV) flow in chronic PVT. In this study, we will review the safety and outcomes of this approach.

Detailed description

Portal vein thrombosis (PVT) is a fairly common complication of liver cirrhosis. Importantly, occlusive PVT might influence the prognosis of patients with cirrhosis. Transjugular intrahepatic portosystemic shunt (TIPS) has been reported to be an effective treatment of PVT in cirrhosis, with the advantage of avoiding the risk of bleeding linked to anticoagulation. In this study, we will evaluate the outcome of TIPS for PVT in patients with and without cirrhosis and determinate survival.

Interventions

PROCEDURETransjugular intrahepatic portosystemic shunt

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Written informed consent * Liver cirrosis or non-cirrhotic patients * Portal vein thrombosis (degree of vessel obstruction \> 50%)

Exclusion criteria

* Active variceal bleeding * Prior history of TIPS placement or shunt surgery * Concomitant renal insufficiency * Severe cardiopulmonary diseases * Uncontrolled sepsis Serious medical conditions which may reduce the life expectancy * Contraindications for TIPS

Design outcomes

Primary

Measure	Time frame	Description
Outcome of TIPS for PVT in patients with and without cirrhosis	5 years	Clinical evolution after placement of TIPS

Countries

Mexico

Contacts

Primary ContactAldo Torre

detoal@yahoo.com54870900

Backup ContactAldo Torre Delgadillo

detoal@yahoo.mx

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026