Molecular Imaging
Conditions
Brief summary
The investigators developed 18F-IRS as a targeted molecular imaging agent for noninvasive and repeatable detecting EGFR-activating mutational status.
Detailed description
The goal of investigators were to evaluate the use of 18F-IRS as a novel PET/CT radiotracer to monitor EGFR-activating mutational status and identify EGFR-TKIs benefit NSCLC patients. the investigators want to evaluated the use of 18F-IRS in lung cancer imaging in adult NSCLC patients with different EGFR mutational status of primary and metastatic cancers.
Interventions
RADIATION18F-IRS
According to experiment, 18F-IRS was non-toxic and stable in serum.
Sponsors
Harbin Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* Advanced NSCLC * 18 years or older * A life expectancy of at least 12 weeks * Presence of a malignant lesion within the chest of at least 0.5 cm diameter as measured by computed tomography (CT) * Written informed consent
Exclusion criteria
* Claustrophobia * Pregnancy * Metal implants in the thorax
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| tumor SUVmax value of 18F-IRS PET/CT Imaging | at time of imaging | To quantify the accumulation, a volume of interest using a 3-D sphere, was placed over the primary lung tumor, lymph nodes and distant metastases avoiding necrosis, blood vessels and normal lung tissue as much as possible on a workstation (Advantage Workstation 4.6; GE Healthcare). The maximum standard uptake value (SUVmax) normalized to body weight (kBq/mL) was calculated within the region of interest. |
Countries
China
Outcome results
None listed