Obesity-asthma Endophenotype and Diaphragm Mobility in Adolescence

Obesity-asthma Endophenotype: Assessment of Diaphragm Mobility and Muscle Inflammation Markers in the Adolescence

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03029936

Enrollment

100

Registered

2017-01-24

Start date

2016-07-01

Completion date

2017-12-01

Last updated

2018-03-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthma, Obesity

Keywords

obesity, asthma, diaphragm excursion, pulmonary function test

Brief summary

Obesity and asthma share changes that may begin in the fetal development phase. The endophenotype obesity-asthma presents as main characteristic a pattern of inflammatory response different from the habitual Th2 profile of cytokines. In these obese patients, possible changes in the diaphragm muscle can directly influence the dynamics of pulmonary ventilation significantly. Due to the importance of the diaphragm in pulmonary ventilation, this study will be performed to verify possible alteration in the excursion and diaphragmatic thickness of adolescents with endophenotype obesity-asthma. In parallel, the possible underlying etiopathogenic substrate of this endophenotype will be explored through the dosing of muscle enzymes and inflammatory cytokines and obesity hormones.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

12 Years to 21 Years

Healthy volunteers

Yes

Inclusion criteria

* Adolescents of both sexes, aged 12-21 years; * For the obesity groups, BMI for gender and age equal to or greater than the 97th percentile; * Clinical diagnosis of persistent, moderate and severe asthma by a specialist physician and its severity classified according to the GINA (Global Initiative Against Asthma) criteria.

Exclusion criteria

* Adolescents with a diagnosis of cardiovascular, rheumatic, osteoarticular, neuromuscular or any other disease that limits the safe performance of the tests proposed by the protocol will be excluded; And those who do not agree to participate in the study.

Design outcomes

Primary

Measure	Time frame	Description
Diaphragm mobility	1 day	Change in mm of diaphragm mobility.

Secondary

Measure	Time frame	Description
Diaphragm thickness	1 day	Change in cm of diaphragm thickness.
Th1 Cytokine Levels	1 day	Change in pg/mL of Th1 Cytokines
Th2 Cytokine Levels	1 day	Change in pg/mL of Th2 Cytokines

Countries

Brazil

Outcome results