Effects of Limb Remote Ischemic Preconditioning for Prevention of Delirium in Elderly Patients After Non-cardiac Surgery

Effects of Limb Remote Ischemic Preconditioning for Prevention of Delirium in Elderly Patients After Non-cardiac Surgery:a Randomised, Double-blind, Placebo-controlled Trial

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03028389

Acronym

LRIP-D

Enrollment

611

Registered

2017-01-23

Start date

2017-02-01

Completion date

2017-02-28

Last updated

2017-01-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Elderly Patients, Non-cardiac Surgery

Keywords

elderly patients, non-cardiac surgery, ischemic preconditioning, delirium

Brief summary

To investigate whether limb remote ischemic preconditioning (LRIP) could safely decrease the incidence of delirium in elderly patients after non-cardiac surgery.

Detailed description

Remote ischaemic preconditioning may confer the cytoprotection in critical organs. We hypothesized that limb remote ischemic preconditioning (RIPC) would safely decrease the incidence of delirium in elderly patients after non-cardiac surgery.The primary outcomes included the incidence of delirium in the first 7 days after surgery using the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) scale.The quality of recovery over a 6-month period was evaluated as well.Secondary endpoints included length of stay in the hospital after surgery (from day of surgery to hospital discharge), occurrence of non-delirium postoperative complications, and all-cause 6-month mortality.

Interventions

PROCEDURElimb remote ischemic preconditioning(LRIP)

LRIP consisted of three cycles of left upper limb ischemia induced by inflating a blood pressure cuff on the left upper arm to 200mmHg, with an intervening 5 minutes of reperfusion, during which time the cuff was deflated.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

TRIPLE (Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

65 Years to No maximum

Healthy volunteers

Inclusion criteria

* elderly patients received elective non-cardiac surgery with general anesthesia * anticipated surgery time \> 2 hours

Exclusion criteria

* age \< 65 years old * Acute coronary syndrome or myocardial infraction within 3 months * Chronic obstructive pulmonary emphysema * Serious hepatic dysfunction (Child-Pugh class C) * serious renal dysfunction (undergoing dialysis before surgery) * Ejection fraction less than 40% * Poor pulmonary function (PaO2 \<60mmHg) * Preoperative history of schizophrenia, epilepsy, Parkinsonism, or myasthenia gravis * Inability to communicate in the preoperative period (coma, profound dementia, or language barrier) * Brain injury or neurosurgery

Design outcomes

Primary

Measure	Time frame
the incidence of delirium	in the first 7 days after surgery

Contacts

Primary ContactJian Liu, MD

launfyy@126.com+86-15013228487

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026