Healthy
Conditions
Brief summary
Healthy volunteers will be recruited. All subjects will be tested a battery of neuropsychological tests, then undergo fluorodeoxyglucose-positron emission tomography (PET) and magnetic resonance imaging (MRI). During the PET and MRI, they will be stimulated with transcranial direct current stimulation (tDCS) for 15 minutes. A third of subjects will receive real tDCS on the left prefrontal cortex, a third on the right prefrontal cortex, and the other third will receive sham tDCS.
Interventions
DEVICEtranscranial direct current stimulation
15 minute anodal stimulation 1.5mA
Sponsors
University of Manitoba
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* N/A
Exclusion criteria
* History of any neurological or psychiatric diseases; * Abnormal MRI; * metal implants or a cardiac pacemaker; * Pregnant or breastfeeding women (female subjects of child bearing potential will be screened for pregnancy before MRI imaging). * severe hypertension. * cardiovascular disease. * Family history of epilepsy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| functional connectivity | immediate (less than 30 minutes) | The functional connectivity of the right caudate nucleus will be estimated using graph theory analysis technique of resting-state fMRI. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Stroop task performance | immediate (less than 60 minutes) | the executive function that is thought to involve the caudate nucleus will be examined |
Countries
Canada
Outcome results
None listed