Effect of Tri Calcium Phosphate on Efficacy and Sensitivity With Vital Tooth Whitening Using 20% Carbamide Peroxide

Effect of Tri Calcium Phosphate Paste on Efficacy and Postoperative Sensitivity Associated With At-Home Vital Tooth Whitening Using 20% Carbamide Peroxide 'A Randomized Controlled Study'

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03026725

Enrollment

Registered

2017-01-20

Start date

2016-11-30

Completion date

2017-02-28

Last updated

2017-04-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tooth Sensitivity

Keywords

tooth sensitivity, tri calcium phosphate, at-home whitening

Brief summary

Teeth sensitivity is the most popular symptom when using At-Home tooth whitening. Tri calcium phosphate containing pastes may affect the efficacy and postoperative sensitivity associated with At-Home vital tooth whitening using 20% carbamide peroxide

Detailed description

Subjects enrolled in this study will apply home bleaching trays with 20%carbamide peroxide 4h/day for a week, the sample will be divided into two groups : the experimental group will apply tri calcium phosphate containing paste(Clinpro) 30 min/day after bleaching treatment, the control group will apply placebo paste 30 min/day after bleaching treatment,

Interventions

OTHERTri-calcium Phosphate

A paste contains Tri Calcium Phosphate & Fluoride

OTHERPlacebo

paste manufactured to mimic Clinpro, without Tri Calcium Phosphate

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Good dental health * Six maxillary anterior teeth present and healthy with no restorations or carious lesions * Teeth darker than Vita A2 shade * No history of teeth sensitivity * No use of a desensitizing agent or desensitizing toothpaste in the past three months

Exclusion criteria

* Active caries or periodontal disease * Allergies to bleaching agent or tray material * pregnancy and breastfeeding during the trial * tetracycline-stained teeth or fluoride or non-vital teeth * Smoker * Using tooth bleaching products during the last 3 years

Design outcomes

Primary

Measure	Time frame	Description
Change in Sensitivity Status	at (1) 24 hours following application, (2) at 48 hours post-application, (3) at 72 hours post-application and (4) at seven days following application	using a visual analog scale (VAS)

Secondary

Measure	Time frame	Description
Change in Color Shade	at (1) 72 hours following application , (2) one week following application, (3) two weeks following application, and (4) one month following application	color shade change will be detected; using Vita Easy Shadeِ Advance 4.0.

Countries

Syria

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026