Heart Failure, Heart Transplantation, Sleep Disordered Breathing Central
Conditions
Keywords
Sleep-Disordered Breathing, Heart Failure, Heart Transplantation
Brief summary
Sleep-disordered breathing is believed to appear at a high prevalence in end-stage heart failure patients and the presence of sleep-disordered breathing has been associated with increased mortality. This study is designed to investigate prevalence and dynamics of sleep-disordered breathing in end-stage heart failure patients pre and post heart transplantation.
Detailed description
Sleep-disordered breathing is believed to appear at a high prevalence in end-stage heart failure patients and the presence of sleep-disordered breathing has been associated with increased mortality. This study is designed to investigate prevalence and dynamics of sleep-disordered breathing in end-stage heart failure patients pre and post heart transplantation, as this topic is hardly studied yet and previous reports suggest changes in the entity of sleep-disordered breathing through heart transplantation. The circumstances and the impact of sleep-disordered breathing or residuals in heart transplant patients is not well understood yet and will be subject of this study.
Interventions
BEHAVIORALSleep-disordered breathing
Prevalence and dynamic of sleep-disordered breathing after heart transplantation
Sponsors
The German Heart Foundation
Deutsche Stiftung für Herzforschung
Heart and Diabetes Center North-Rhine Westfalia
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* End-stage heart failure patients assigned and eligible for heart transplantation
Exclusion criteria
* heart failure patients not eligible for heart transplantation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Apnea Hypopnea Index | 30 days after heart transplantation | Change in Apnea Hypopnea Index (AHI /h) before and after heart transplantation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hypopnea Index | 30 days after heart transplantation | Change in Hypopnea Index (HI /h) before and after heart transplantation |
| Oxygen Desaturation Index | 30 days after heart transplantation | Change in Oxygen Desaturation (ODI /h) before and after heart transplantation |
| Time SaO2 < 90 (%) | 30 days after heart transplantation | Change in Time SaO2 \< 90 (%) before and after heart transplantation |
| Apnea Index | 30 days after heart transplantation | Change in Apnea Index (AI /h) before and after heart transplantation |
| Health Questionnaires | 30 days after heart transplantation | Change in MLWH questionnaire, this questionnaires obtains patient's quality of life in a score (in points) |
| Right heart catheter | 30 days after heart transplantation | Changes in right heart catheter before and after heart transplantation |
| Blood gas analysis | 30 days after heart transplantation | Changes in blood gas analyses before and after heart transplantation |
| Respiration cycle length | 30 days after heart transplantation | Change in Respiration cycle lengths before and after heart transplantation |
Countries
Germany
Outcome results
None listed