Effect of Pulmonary Recruitment Maneuver (PRM) on Pain and Nausea After Laparoscopic Cholecystectomy

A Prospective, Blinded, Randomized Clinical Trial Investigating the Effect on Postoperative Pain and Nausea, When Performing a Ventilator-piloted PRM at the End of Laparoscopic Cholecystectomy

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03026543

Enrollment

260

Registered

2017-01-20

Start date

2014-10-31

Completion date

2018-12-31

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain, Postoperative, Postoperative Nausea and Vomiting

Brief summary

This prospective, blinded, randomized clinical trial investigates the effect on postoperative pain and nausea, when performing a ventilator-piloted PRM at the end of a laparoscopic cholecystectomy.

Interventions

PROCEDUREPulmonary Recruitment Maneuver

PROCEDURELaparoscopic cholecystectomy

DEVICEVentilator

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* elective laparoscopic cholecystectomy * American Society of Anesthesiologists (ASA) physical status classification I-II (with the exception of body mass index over 35 kg/m2) * written consent

Exclusion criteria

* conversion to open surgery * Clavien-Dindo grade ≥ II

Design outcomes

Primary

Measure	Time frame	Description
Change in postoperative pain assessed with a numeric rating scale	4, 12, 24, 36 and 48 hours after surgery	A questionnaire with a numeric rating scale (NRS) is used to assess pain intensity at 4, 12, 24, 36 and 48 hours postoperatively.

Secondary

Measure	Time frame	Description
Change in postoperative nausea assessed with a Questionnaire	4, 12, 24, 36 and 48 hours after surgery	A questionnaire is used to evaluate nausea at 4, 12, 24, 36 and 48 hours postoperatively.

Countries

Sweden

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 14, 2026