Liver Cancer
Conditions
Brief summary
To evaluate the safety and efficacy of ultrasonography (US) -guided radiofrequency ablation for liver tumors, the investigators used preoperative and postoperative US/CEUS(contrast-enhanced ultrasonography)/CT/MRI to assess lesions, and laboratory tests including the tumor markers to evaluate the general condition of patients. Intraoperative US/CEUS/CT would be applied to monitor ablation lesions.
Interventions
PROCEDUREUS-guided RFA
The investigators used percutaneously US-guided radiofrequency ablation for patients with small hepatocellular carcinoma,and estimated the safety and efficacy of this treatment through 2-year follow-up of US/CEUS/CT/MRI and the tumor markers.
Sponsors
First Affiliated Hospital of Zhejiang University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with small hepatocellular carcinoma (single or multiple nodules of less than 3 cm in diameter), Patients with Child-Pugh A/B, Patients with PLT(platelet count) ≥ 50\*10e9/L and PT(prothrombin time) ≤ 20s.
Exclusion criteria
* Patients with blood coagulation dysfunction, ChildPugh score≥3, severe cardiopulmonary disease, intolerant anesthesia and upper gastrointestinal bleeding in shock.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Tumor size assessed by MRI | through study completion, an average of 2 year | Tumor size was estimated by MRI. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Carcinoembryonic Antigen (CEA) level assessed by ELISA | through study completion, an average of 2 year | CEA level was assessed by enzyme linked immunosorbent assay (ELISA). |
| Alpha Fetoprotein (AFP) level assessed by ELISA | through study completion, an average of 2 year | AFP level was assessed by ELISA. |
Countries
China
Outcome results
None listed