Lipid Encapsulation for Ileal Brake Activation

The Effect of Orally Applied Encapsulated Lipids in Yoghurt on Satiety and Food Intake: a Randomized Single-blind Placebo-controlled Study With Cross-over Design

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03025997

Enrollment

Registered

2017-01-20

Start date

2017-01-24

Completion date

2017-03-31

Last updated

2017-11-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Appetite Regulation

Brief summary

This study evaluates the ability of encapsulation of orally applied lipids in a yoghurt snack to modify ad libitum food intake and satiety, without GI symptoms. Every subject receives two treatments (active, and placebo) on two different days, following a randomized cross-over design.

Interventions

DIETARY_SUPPLEMENTActive yoghurt

Active yoghurt (containing encapsulated lipid) will be ingested after a standardized breakfast, and subsequently satiety and food intake will be measured.

DIETARY_SUPPLEMENTPlacebo yoghurt

Placebo yoghurt (containing non-encapsulated lipid) will be ingested after a standardized breakfast, and subsequently satiety and food intake will be measured.

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

PREVENTION

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* BMI between 25-30 kg/m2 * Voluntary participation

Exclusion criteria

* Milk (-protein or lactose)- allergy/intolerance * History of serious GI complaints/surgeries * Pregnancy, lactation * Excessive alcohol consumption (\>20 per week) * Abnormal eating behaviour * Intention to stop smoking * Reported unexplained weight loss or gain in the month prior to screening * Self-admitted HIV-positive state

Design outcomes

Primary

Measure	Time frame	Description
ad libitum food intake	2 hours after yoghurt snack	t=0: standardized breakfast, t=90 minutes: yoghurt, t=210 minutes: ad libitum food intake

Secondary

Measure	Time frame	Description
occurrence and severity of GI symptoms	Up to 3.5 hours on each of the 2 test days.	Every 15-30 min, 4 attributes will be measured on a Visual Analogue Scale
Satiety feelings	Up to 3.5 hours on each of the 2 test days.	Every 15-30 min, 5 attributes will be measured on a Visual Analogue Scale

Countries

Netherlands

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026