Nasopharyngeal Carcinoma
Conditions
Brief summary
The purpose of this clinical research project is to explore potential biomarkers and validate the predictive and prognostic value of molecular signature in nasopharyngeal carcinoma.
Detailed description
Objectives: Primary: Evaluation of failure-free survival after three years of patients of nasopharyngeal carcinoma. Secondary: Evaluation of overall survival after three years of patients of nasopharyngeal carcinoma. Outline: This is a multicenter observational study. Tumor tissue specimens are obtained from the Sun Yat-sen University Cancer Center and Affiliated Hospital of Guilin Medical University. The samples are analyzed for biomarkers. The biomarkers are correlated with clinical outcomes (failure-free survival, overall survival, tumor response to treatment, distant metastasis, recurrence and death). The aim of the analysis is to explore potential biomarkers and validate the predictive and prognostic value of molecular signature in nasopharyngeal carcinoma. This will lead to the definition of risk groups and stratification of patients and will help to precision medicine of nasopharyngeal carcinoma.
Interventions
None listed
Sponsors
Guilin Medical University, China
First People's Hospital of Foshan
Sun Yat-sen University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patients with newly histologically confirmed nasopharyngeal carcinoma * No evidence of distant metastasis (M0) * Written informed consent
Exclusion criteria
* Treatment with palliative intent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Failure-free Survival | 3 years |
Secondary
| Measure | Time frame |
|---|---|
| Overall Survival | 3 years |
Countries
China
Contacts
Primary ContactJun Ma, M.D.
Outcome results
None listed