Sepsis
Conditions
Keywords
Molecular diagnosis, Pathogen identification, Sepsis, Bacteremia, Rapid diagnostics
Brief summary
The FAPIC project will develop a diagnostic system that will identify pathogens and charachterize virulence and resistance. A prospective study will be performed in which blood samples will be collected of patients with suspected sepsis in order to evaluate the diagnostic system. In routine care, blood is drawn of these patients for culture in order to identify the causative pathogen. This process takes 3-5 days. During the study, one extra blood sample will be collected with the same venipuncture, with each blood culture. Afterwards, routine diagnosis by blood culture is followed. Blood samples will be send to the research laboratories for determination of sensitivity and specificity. The system will not be used in the clinic.
Interventions
None listed
Sponsors
AIT Austrian Institute of Technology GmbH
University of Zagreb
Jessa Hospital
Hasselt University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Older than 18 years * Suspicion of bacteremia
Exclusion criteria
* Children (\<18 years)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Detection of pathogens and its virulence factors and susceptibility genes | 1 year | Sensitivity, specificity, and accuracy of the molecular system compared to blood culture. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Population outcome during routine procedures | 1 year | Insights on routine hospital procedures using blood culture and outcomes on the study population such as TAT, antimicrobial use, time to antimicrobial change, in-hospital stay, and mortality by collection of patient data in the medical records. |
Countries
Belgium, Croatia
Outcome results
None listed