Dietary Intake of Alpha-linolenic Acid in Elderly

Investigation of the Relationship Between Alpha-linolenic Acid and Arterial, Biochemical, Biological Parameters in Older Persons With History of Cardiovascular Events and/or Moderate Cognitive Impairment

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03025620

Enrollment

254

Registered

2017-01-19

Start date

2006-11-30

Completion date

2011-12-31

Last updated

2017-01-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular Diseases, Inflammation, Metabolism Disorder, Lipid

Keywords

Alphalinolenic acid, Lipid cardiovascular risk factors, Inflammation

Brief summary

The purpose of this study is to evaluate the antiatherogenic and anti-inflammatory potential of an adequate intake of alpha-linolenic acid in elderly.

Detailed description

There is growing evidence that diets high in long chain n-3 polyunsaturated fatty acids (PUFA) decrease the risk of fatal ischemic heart disease.Both epidemiologic studies and clinical trials demonstrate substantial cardioprotective effects of alpha linolenic acid (ALA) from vegetable oils.However, little is known about the relation of the dietary intake of ALA with ischemic heart disease among older adults.In this study, elderly volunteers will be asked to ingest a supplement of a vegetable oil providing 1g of ALA, or an equivalent amount of linoleic acid as sunflower oil, for a diet period of 6 weeks.Serum samples will be collected before the dietary intervention and 6 weeks later.Plasma biomarkers of inflammatory, lipid cardiovascular risk factors and serum and red cell membrane fatty acid composition will be determined on all samples.

Interventions

DIETARY_SUPPLEMENTRapeseed oil

Active comparator arm : Dietary Supplement: rapeseed oil supplementation (10g per day) and margarine with a high level of alpha-linolenic acid (12.5g per day) during 42 days.

DIETARY_SUPPLEMENTSunflower oil

Placebo comparator arm : Dietary Supplement: sunflower oil supplementation (10g per day) and margarine with a high level of inoleic acid (12.5g per day) during 42 days.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

TRIPLE (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

65 Years to No maximum

Healthy volunteers

Inclusion criteria

* Elderly patients over 65 years old exhibiting clinical indices of cardiovascular disease * Male or female * Subjects who were hospitalized in the Geriatric Unit of the Emile Roux Hospital (AP-HP) * MMSE (Mini Mental State Examination)score \> or = 15 * Supervision available for study medication * Able to ingest oral diet

Exclusion criteria

* Patients unable to understand the objectives of the dietary intervention * Patients in paliative care * Patients receiving supplement diets

Design outcomes

Primary

Measure	Time frame	Description
Effects of diet supplementation on fatty acid composition in serum and red cell membrane phospholipids, at the end of dietary period	6 weeks	Blood samples have been done at the beginning and at the end of the dietary period. Fatty acids analyses of the red cells and serum have been performed by GC method.

Secondary

Measure	Time frame	Description
Pulse wave velocity (PWV)	6 weeks	Pulse wave velocity values have been performed at the beginning and the end of the dietary period. The purpose was to evaluate the relationship between PWV and dietary intakes of ALA.
Others	6 weeks	ApoB ApoA1 Oxydative parameters (ie CRP) Lp(a)

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026