Asthma, Healthy
Conditions
Keywords
Breath pattern, Children, Repeatability
Brief summary
Within-day and Between-day Repeatability of the Breath Pattern in Healthy Children and in Children With Moderate Asthma is an observational prospective study in outpatient clinic of Pediatric Allergology & Pulmonology (PAP) within the Institute of Biomedicine and Molecular Immunology (IBIM) of the National Research Council (CNR) of Palermo (IBIM CNR), Italy. The electronic nose (E-nose) has been proposed as a novel, non-invasive tool to evaluate the level of airway inflammation for different respiratory diseases, especially in children. To date, there are no data on the within-day and the between-day repeatability of the breath pattern in healthy children and in children with moderate asthma. The breath pattern will be analyzed by collecting, for each child, three samples of the breath through the E-nose. Within-day repeatability will be assessed using two consecutive measurements (the second one after 30 minutes). Between-day repeatability will be assessed using a third measurement repeated after 7 days. The study is expected to provide information about the accuracy of E-nose measurements for a child population.
Interventions
OTHERAssessment of E-nose measurements
Breath sampling through E-nose pneumopipe
Sponsors
Campus Bio-Medico University
Istituto per la Ricerca e l'Innovazione Biomedica
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
6 Years to 11 Years
Healthy volunteers
No
Inclusion criteria
The inclusion criteria for asthmatic children are: 1. Moderate asthma (GINA 2015); 2. Age 6-11 years; 3. No upper airway respiratory infections or exacerbations in the last 4 weeks; 4. Steroid-naive asthma; 5. Positive bronchodilator response; 6. Non smoker. The inclusion criteria for healthy children are: 1. Age 6-11 years; 2. No upper airway respiratory infections in the last 4 weeks; 3. Non smoker; 4. No history of asthma and respiratory diseases during the life; 5. Negative bronchodilator response. The
Exclusion criteria
are: 1. Symptoms of acute respiratory infection; 2. Immunological and metabolic systemic disease; 3. Major malformations of the upper airways; 4. Active smoker.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Electronic nose measurements | 1 week | Several volatile organic compounds, including isoprene, 1,2-pentadiene, acetone, ethanol, pentane and ethane, identified in exhaled breath. |
Secondary
| Measure | Time frame |
|---|---|
| Fraction of Exhaled Nitric Oxide (FeNO) | 1 week |
| Pulmonary function (FEV1, FVC, etc.) | 1 week |
Countries
Italy
Outcome results
None listed