Healthy, Obesity
Conditions
Keywords
Motilin, Erythromycin, Food intake
Brief summary
In this study, the investigators aimed at evaluating the role of motilin in the regulation of food intake. Motilin, a gastrointestinal hormone, is a hunger signal in healthy volunteers and is significantly increased in obese patients. Its role in food intake regulation might contribute to the pathogenesis of obesity.
Interventions
DRUGErythromycin
DRUGSaline
Sponsors
Universitaire Ziekenhuizen KU Leuven
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI \< 30 kg/m² for lean volunteers * BMI \> 30 kg/m² for obese volunteers * Subject is capable and willing to give informed consent * Female volunteers of child bearing potential must use oral, injected or implanted hormonal methods of contraception
Exclusion criteria
* Female volunteer is pregnant or breastfeeding * GI diseases, major abdominal surgery * Major psychiatric illnesses * Volunteers that use drugs affecting the GI tract or the central nervous system * Volunteers suffering from endocrine diseases such as diabetes, Cushing's disease, Addison's disease, hypothalamic tumor * Volunteers that have undergone surgical procedure for weight loss
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in food intake, assessed by caloric intake, after intravenous administration of erythromycin compared to placebo | Caloric intake will be assessed 1 hour after the start of infusion and the start of ad libitum food intake |
Secondary
| Measure | Time frame |
|---|---|
| Frequency of food intake correlated with motilin plasma levels | Assessment will be done over a period of 5 hours |
Outcome results
None listed