Children, Liver Transplantation
Conditions
Keywords
Propofol, Neurocognitive Disorders, Liver transplantation, Pediatrics, Brain Injuries
Brief summary
To study the effect of different anaesthetic methods on pediatric neurocognitive development and cerebral injury during pediatric living related liver transplantation .
Detailed description
Since the 1960 s, with the successful development of liver transplantation, it has become an important method for the treatment of patients with end-stage liver disease.Biliary atresia1 is the most frequent causes of pediatric end-stage liver disease,.The morbidity of congenital biliary atresia is 1/8000-18, 0002 ,which influence the patients' overall growth and development situation. The rising of living donor liver transplantation has provide children with the chance of a timely treatment since the 1980 s, It is no doubt that pediatric liver transplantation is facing with many complications, including the most importance of neurocognitive development .Now the researches of neurological complications is less .According to statistics, the incidence of neurological complications after pediatric liver transplantation was 8% - 46% . So it is necessary to research the neurological complications and brain protection strategy .Previous studies have studied that some anaesthetic have uncertain affect on the development of children.
Interventions
DRUGSevoflurane
Sevoflurane: 1%\ 2%
DRUGPropofol
Propofol: 9-15 mg/kg/h
Sponsors
Tianjin First Central Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
4 Months to 12 Months
Healthy volunteers
No
Inclusion criteria
* Children with end-stage liver disease Children with biliary atresia
Exclusion criteria
* pre-existing cerebral disease second liver transplantation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evidence of cerebral injury including S-100 β protein, neurospecific enolase confirmed by electrochemiluminescence | before skin incision, 0.5 hour after anhepatic,1 hour of neohepatic stage,the end of surgery,24 hours after operation |
| Evidences of inflammatory factor such as interleukin-6，interleukin-10，et al confirmed by electrochemiluminescence | before skin incision, 0.5 hour after anhepatic,1 hour of neohepatic stage,the end of surgery,24 hours after operation |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of neurocognitive disorder using Bayley Scales of Infant Development | 1 day before surgery, 7days,14 days and 21days of post-operation |
| Evaluation of delirium using Pediatric Anesthesia Emergence Delirium | Within 1 days after extubation |
| hemodynamics index | before skin incision, 0.5 hour after anhepatic,1 hour of neohepatic stage,the end of surgery,24 hours after operation |
Countries
China
Outcome results
None listed