Renal Transplantation
Conditions
Keywords
Transplantation;perfusion machine
Brief summary
When the kidneys are perfused on perfusion machines before transplantation, the resistance parameters as well as the histological score on the pre-implantation biopsy participate in the evaluation of the quality of the graft. The metabolomic profile of the infusion fluid could provide additional evidence.
Detailed description
The quality of the renal transplant prior to transplantation is essential for the recovery of graft function in the days following transplantation and its long-term survival. When the kidneys are perfused on perfusion machines before transplantation, the resistance parameters as well as the histological score on the pre-implantation biopsy participate in the evaluation of the quality of the graft. The metabolomic profile of the infusion fluid could provide additional evidence.
Interventions
DEVICELifePort® perfusion machine
Renal perfusion on LifePort® machine
Sponsors
Laboratory of Biochemistry, University François Rabelais of TOURS
University Hospital, Tours
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Intervention model description
Metabolic assessment in Urine and perfusion liquids
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Donors aged 18 years or more in brain death or who died of cardiac arrest collected locally in Tours, associated with the major local recipients of the grafts over the same period.
Exclusion criteria
* Kidney transplant removed but stored in a static preservative. * Kidney grafts of donors aged 18 years or more, removed and not retained on a LifePort® perfusion machine.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| IGF | 7 days | Immediate Graft Function (IGF), defined by serum creatinine less than 250 μM / L at day 7 post-kidney transplant, without requiring dialysis of the recipient patient. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| DGF | 7 days | DGF Delayed graft function : Dialysis need within 7 days post-transplant |
| BANFF-1 | PRE-OPERATIONAL | Anatomo-pathological classification of the pre-implantation biopsy according to the revised Banff classification 2013 |
| BANFF-2 | 3 months | Anatomo-pathological classification of systematic biopsy at 3 months post-transplant according to the revised Banff classification 2013 |
Countries
France
Outcome results
None listed