Psychotic Disorders
Conditions
Brief summary
Cognitive remediation (CR) is the best treatment to improve neurocognitive abilities for individuals with psychosis, however, there is no gold standard method of cognitive remediation available. Cognitive training refers to the training component of CR in which people practice computerized exercises that train specific cognitive abilities. There is no agreed upon approach within the field as to the type of training that is most effective with some studies, training higher level cognitive abilities, some training perceptual abilities, and others training general cognitive skills. This study will directly compare two competing methods of cognitive training on measures of neurophysiology, neurocognition, functional competence, and real-world functional performance.
Interventions
BEHAVIORALCognitive Remediation - Executive Training
Cognitive remediation is a cognitive and behavioural therapy designed to improve cognitive skills such as memory, and problem solving ability.
BEHAVIORALCognitive Remediation - Perceptual Training
Cognitive remediation is a cognitive and behavioural therapy designed to improve cognitive skills such as attention, and processing speed.
Sponsors
Queen's University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* psychotic disorder * No previous cognitive remediation in past 6 months
Exclusion criteria
* Brain injury * Substance abuse * Neurocognitive disorder * Developmental Disability
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Functional Performance - Specific Levels of Functioning (SLOF) from Baseline | Post-treatment (within 2 weeks following the end of treatment) | Rating scale completed by participants' case managers that rates their ability to perform different everyday tasks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Neurocognition - MATRICS Cognitive Consensus Battery (MCCB) from Baseline | Post-treatment (within 2 weeks following the end of treatment) | The MCCB is the gold standard cognitive assessment for schizophrenia research |
| Change in Neurophysiology - EEG from Baseline | Post-treatment (within 2 weeks following the end of treatment) | Alpha and Theta band synchronization, p300, mismatch negativity |
| Functional Competence - Canadian Objective Assessment of Life Skills Brief (COALS-B) from Baseline | Post-treatment (within 2 weeks following the end of treatment) | Performance based measure of real life functional skills using role-play |
| Change in Functional Performance - Specific Levels of Functioning (SLOF) from Baseline | Follow-Up (3 months after the end of treatment) | Rating scale completed by participants' case managers that rates their ability to perform different everyday tasks |
Countries
Canada
Outcome results
None listed