Ischemic Stroke
Conditions
Keywords
youth; etiology; prognosis; recurrence; biomarkers
Brief summary
This is a multi-center, prospective,continuous registry study. The investigators will include 3000 young adult (18-45 years old) patients with confirmed first-ever acute ischemic stroke in China. The main purpose of this study is to build the study cohort of young ischemic stroke patients in China, and to compare the prognosis and stroke recurrence of young patients with different ischemic stroke subtypes. Secondary objectives are trying to find biomarkers of stroke recurrence.
Detailed description
Approximately 10%-14% of all ischemic strokes occur in young adults ages 18 to 45 years old. Stroke etiology in this population differs by geographic region and has greater heterogeneity than in older individuals. Ascertain the definite etiologic classification in this young patients might be the key point to prevent the stroke recurrence and reduce the stroke burden. Advances in stroke diagnostic tests, particularly neuroimaging, refinement in classification schema. In this multi-center registry study conducted in China, we determine to explore the difference of prognosis and stroke recurrence of young patients with different ischemic stroke subtypes.
Interventions
OTHERTreatment following current guidelines
Treatment following current guidelines
Sponsors
Jiujiang No.1 People's Hospital
Dezhou People's Hospital
The Affiliated Hospital of Yanbian University
First Affiliated Hospital of Jiamusi University
Xuchang Central Hospital
Inner Mongolia People's Hospital
Shaoxing People's Hospital
Chinese PLA General Hospital
General Hospital of Ningxia Medical University
General Hospital of Shenyang Military Region
Siping Central People's Hospital
The First Affilated Hospital of the Medical College, Shihezi University
Daqing Oilfieled General Hospital
Heilongjiang Provicial Hospital
The First Affiliated Hospital of Soochow University
Luoyang Central Hospital Affilated to Zhengzhou University
Wuzhou Red Cross Hospital
Cangzhou Central Hospital
Binzhou Medical University
Affilated Hospital of Inner Mongolia University for the Nationalities
Fudan University Pudong Medical Center
Yi Yang
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Age 18 through 45 years, both genders * First-ever acute ischemic stroke * Onset of symptoms within 72 hours of inclusion * Willing to participate in follow-up visits
Exclusion criteria
* Silent stroke * Failure to give their informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Stroke recurrence | 1 year | Percentage of patients with the 1 year new vascular events, defined as any event of the following: Any stroke (ischemic or hemorrhage) |
| Post-stroke disability | 3 months | Modified Rankin Scale score changes (continuous) and dichotomized at percentage with score 0-2 vs. 3-6 at 3-month follow-up. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cardiovascular death | 3 months, 6 months and 1 year | Percentage of patients with the 3-month, 6-month and 1 year cardiovascular death caused by any event of the following: Any stroke (ischemic or hemorrhage), sudden cardiac death, acute myocardial infarction, heart failure, and other cardiovascular death including pulmonary embolism, rupture of aortic aneurysm, cardiovascular interventional therapy, and peripheral arterial disease. |
| Other cardiovascular event | 3 months, 6 months and 1 year | Percentage of patients with the 3-month, 6-month and 1 year other cardiovascular event including non-lethal myocardial infarction, and non fatal heart failure. |
| Other systemic embolism | 3 months, 6 months and 1 year | Percentage of patients with the 3-month, 6-month and 1 year other systemic embolism except for cerebral artery, coronary artery, and pulmonary artery. Such as mesenteric arterial embolism,splenic artery embolization. |
Countries
China
Contacts
Primary ContactYi Yang, MD,PhD
Backup ContactZhenni Guo, MD
Outcome results
None listed