Lung Injury, Acute
Conditions
Keywords
Lung, Cardiopulmonary Bypass, Pediatric, Cardiac surgery
Brief summary
The lung is at risk for ischemic insults during total cardiopulmonary bypass because lung perfusion is maintained solely by the bronchial arterial system
Detailed description
The study will be performed in the pediatric cardiothoracic unit, pediatric Assiut University Hospital. After obtaining approval from the local ethics committee and written informed parents consent 60 patients will be included in this study according to the following criteria:
Interventions
PROCEDUREcardiopulmonary bypass
Low flow of mixed oxygen / air (1:1L) will be used during the period of cardiopulmonary bypass
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
2 Years to 10 Years
Healthy volunteers
No
Inclusion criteria
* Elective cardiac surgery * Ventricular septal defect (VSD). * Atrial septal defect (ASD)
Exclusion criteria
* Cyanotic heart disease. * Patients with preoperative chest problems. * Patients with known renal or hepatic dysfunctions. * Planned off-pump cardiac surgery. * Emergency cardiac surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from Baseline Computerized tomography chest (CT chest) within 7 days postoperative | preoperative and within the first 7 days postoperative |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mechanical ventilation | Within the first 7 days postoperative | Duration of mechanical ventilation (hours) |
| Intensive care unit stay | Within the first 7 days postoperative | Intensive care unit stay |
| Intubation time | Within the first 7 days postoperative | Intubation time (hours) |
| Arterial blood gases | Within the first 7 days postoperative | Intraoperative and postoperative by appropriate scale |
Countries
Egypt
Outcome results
None listed