Detection of Arousal With Facial Micro-expression in Severe Brain-damaged Patient

Status

Terminated

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03023657

Acronym

DAME

Enrollment

Registered

2017-01-18

Start date

2017-06-23

Completion date

2017-10-16

Last updated

2022-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Consciousness Disorder

Keywords

arousal, Consciousness Disorders, vegetative state, minimally conscious state

Brief summary

Severe brain injuries lead to disorders of consciousness after coma. During this awakening period, detection of arousal is critical to the adaptation of medical strategy, but global paralysis, including facial expression, make the clinical assessment very difficult. Emotional facial expressions are a significant part of this clinical assessment. They are both a landmark of the internal state of the patient (comfort versus discomfort) and a landmark of the relational level with his environment. Visible emotional facial expression is a large temporal phenomenon lasting a couple of seconds, while a microexpression is barely noticeable and very brief. These micro expressions are usually produced when one tried to voluntary hide emotional expressions. In this study, we hypothesize that some patients awakening from coma could still produce microexpression before being able to produce visible emotional facial expressions. This ability to produce micro-expression could be an early landmark of relational awakening in severe brain lesions.

Interventions

OTHERDetection of arousal

Detecting facial microexpression before visible facial expressions in patient with disorder of consciousness after severe brain injury

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

Inclusion criteria

* Brain-damaged patient (stroke, traumatic brain injury, anoxia) * Disorder of consciousness (CRS-R≤ 10) more than 48h after stopping sedation * Patient without spontaneous or stimulated facial expressions

Exclusion criteria

* Medically unstable patient

Design outcomes

Primary

Measure	Time frame	Description
facial micro expression found in at least one patient on one video recording	Every day for a week then once a week for four weeks	Optical camera and thermal camera

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026