Hematologic Neoplasms, Solid Neoplasm
Conditions
Brief summary
This study seeks to evaluate the clinical utility of the Precision Medicine Molecular Tumor Board, and to track patient outcomes.
Interventions
PMMTB is a clinical intervention, NOT a research intervention. The research component of this study is to observe the outcomes of the PMMTB.
Sponsors
Study design
Eligibility
Inclusion criteria
* Clinically suspected or histologically confirmed solid or hematological malignancy * Undergoing genetic testing of tumor * Ability to understand written informed consent document * Willingness to sign written informed consent document
Exclusion criteria
* Pediatric patients (age\<18 years) will be excluded due to a lack of expertise on the molecular tumor committee
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Frequency of acceptance of molecular tumor board recommendations | Up to 5 years | How often the molecular tumor board's recommendations are accepted |
| Benefit from PMMTB recommended treatment | Up to 5 years | Whether patients benefit from PMMTB recommended treatment |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation of mutations with protein overexpression | Up to 5 years | Correlate mutations identified in tumor tissue with protein overexpression |
| Correlations of mutations with circulating tumor DNA | Up to 5 years | Correlate mutations identified in tumor tissue with circulating tumor DNA |
| Correlations of mutations with spheroid culture investigations | Up to 5 years | Correlate mutations identified in tumor tissue with spheroid culture investigations |
Countries
United States
Contacts
University of Wisconsin, Madison