AIDS, HIV
Conditions
Keywords
PMTCT, MNCH
Brief summary
The goal of this proposed intervention study is to increase the proportion of HIV positive and HIV negative pregnant women who deliver in a facility, the proportion of HIV exposed infants (HEI) who receive nevirapine (NVP) within 48 hours of delivery, and the proportion of HEI who are bled for HIV polymerase chain reaction (PCR) deoxyribonucleic acid (DNA) testing within 8 weeks of age.
Detailed description
Following a formative phase I, we propose in phase II to implement a three-group cluster-randomized study to test the effectiveness of short message service (SMS) reminders and notifications, \[mobile health or mhealth\] (group 1) and the combined effectiveness of SMS reminders/notifications and cash transfers (group 2) compared to the standard prevention of mother-to-child transmission (of HIV)/maternal, neonatal and child health, (PMTCT/MNCH) practices (group 3).
Interventions
BEHAVIORALmHealth messaging
SMS appointment reminders and health messaging via mobile phones
BEHAVIORALTransport Payments
A payment scaled to reflect the cost of typical return transport fare for residents of the clinic catchment area
Sponsors
Population Council
Ministry of Health, Tanzania
Elizabeth Glaser Pediatric AIDS Foundation
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Known or recently diagnosed HIV-positive in ANC or; Tested HIV-negative at ANC * Plans to deliver in facility catchment area * 18 years or older * Able and willing to provide consent
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Nevirapine (NVP) at delivery | 1 year | Proportion of HEI given NVP at delivery |
| Attendance for Early infant diagnosis (EID) of HIV | 1 year | Proportion of HIV-exposed infants (HEI) attending for early infant diagnosis of HIV (DBS collected) by 8 weeks |
| Early identification of HEI at Reproductive and Child Health (RCH) Clinic | 1 year | Proportion of HEI identified early (48 hours,3 and 7 days) at RCH clinic |
| Antenatal care (ANC) visits | 1 year | Proportion of pregnant women attending at least 4 ANC visits |
| Facility delivery | 1 year | Proportion of pregnant women delivering in a health facility |
| Post natal care (PNC) visits | 1 year | Proportion of post partum women attending PNC 48 hours, 3 and 7 days post delivery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| HIV infected infants initiated on antiretroviral therapy (ART) | 1 year | Proportion of HIV infected infants initiated on ART by 12 weeks of age |
| Time to EID | 1 year | Time (days/weeks) from date of birth to attendance for EID |
| Time to receipt of EID results | 1 year | Time (days/weeks) from date of birth to receipt of EID results |
| Time to treatment | ! year | Time (days/weeks) from date of birth to initiation of ART |
| Receipt of EID results | 1 year | Proportion of HEI who received EID results by 12 weeks |
Countries
Tanzania
Outcome results
None listed