Ammonia Metabolism
Conditions
Brief summary
L-carnitine is synthesized from lysine and methionine. Postmortem concentrations of carnitine in liver, muscle, heart, kidney, and brain averaged only one-fourth to one-third those in corresponding tissues of eight normally nourished non-hepatic patients who died after an acute illness of a 1-3-day duration. In the recent years, it has been reported that sirtuin 3 (SIRT3) is protective against acute kidney injury (AKI) and suggest that enhancing SIRT3 to improve mitochondrial dynamics has potential as a strategy for improving outcomes of renal injury. In the current study, it is the first clinical interventional research whether L-carnitine corrects ammonia metabolism associated with liver injury in hepatectomized patients.
Interventions
DRUGL-carnitine
treatment with oral L-carnitine, 1500 mg/body per day
OTHERusual intake
baseliner
Sponsors
Kochi University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* patients were those surgically treated for hepato-biliary diseases
Exclusion criteria
* Patient
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| postoperative ammonia levels | 3 points; preoperative baseline, postoperative day 1, and day3 | change from preoperative baseline at postoperative day 1 and day3 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| length of hospitalization after liver resection | up to 24 weeks | postoperative days |
Countries
Japan
Contacts
Primary ContactTakehiro Okabayashi, MD
Outcome results
None listed