Chronic Obstructive Pulmonary Disease Moderate
Conditions
Keywords
Dietary nitrate, Physical performance, Blood pressure, Nitrite, Exercise
Brief summary
The purpose is to evaluate exercise performance in patients with Chronic Obstructive Pulmonary Disease (COPD) after supplementing with higher doses of dietary NO3-, compared to previous studies, as beetroot juice for seven days. The secondary purpose is to evaluate oxygen consumption of submaximal cycling, amendments in blood pressure, and physical activity level.
Detailed description
The purpose is to evaluate exercise performance in patients with Chronic Obstructive Pulmonary Disease (COPD) using the 6-minute walk test (6MWT) after supplementing with higher doses of dietary NO3- compared to previous studies, as beetroot juice for seven days. The secondary purpose is to evaluate oxygen consumption of submaximal cycling, amendments in blood pressure, and physical activity level.
Interventions
DIETARY_SUPPLEMENTDietary beetroot juice
Consumed as concentrated beetroot juice from James White Drinks England (Beet-it) and contained 300 mg dietary nitrate. Dose: 2x70 mL consumed twice a day for six days.
Sponsors
University of Aarhus
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Moderate-severe Chronics Obstructive Pulmonary Disease (COPD) (FEV1 \<80% of predicted).
Exclusion criteria
* Smoking, * failure to complete physical testing, * on-going participation in rehabilitation programs, * pacemaker or use of nicotine products, * oxygen mask, * beta blockers, * antibacterial mouthwash, * chewing gum or stomach-neutralizing medicine during the intervention.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Physical performance on 6-min walk test (6MWT) | 6 minutes |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Blood Pressure | At baseline and 150 minutes after consumption of beverages | — |
| Plasma Nitrite concentration | Baseline, 150 and 210 minutes after consumption of beverages | — |
| Oxygen consumption during submaximal cycling | Two trials of 6 minutes duration (10 min break between trials) | — |
| Physical activity level | Six days | Measured all intervention days except on the day of testing |
Countries
Denmark
Outcome results
None listed