Urinary Tract Infections
Conditions
Brief summary
The main focus of this observational study is to analyze the possible effects of cranberry dietary supplements on the intestinal microbiota in women with recurrent uncomplicated urinary tract infections. In a secondary analysis the possible influence of the microbiota changes on the recurrence frequency in the follow-up should be analyzed.
Interventions
DIETARY_SUPPLEMENTCranberry Extract
3 x Cystorenal Cranberry plus daily for 6 months (contains 300 mg Cranberry-Extract, 100 mg Pumpkin seeds-Extract, 20 mg Vitamin C und 0,47 mg Riboflavin)
Sponsors
Charite University, Berlin, Germany
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
• chronic recurrent urinary tract infections (≥3 infections per year or 2 infections in the last 6 months)
Exclusion criteria
* renal insufficiency (GFR \<60), * anatomical or known structural causes of urinary tract infections * regular consumption of probiotics or probiotic yogurts (at least 5x / week) * intake of antibiotics in the last 4 weeks * intake of Marcumar * simultaneous participation in another study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of urinary tract infections | In the 6-month prospective observation period compared to a 6-month retrospective period |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life (SF-36) | Baseline, 4 weeks, 8 weeks, 6 months |
Other
| Measure | Time frame |
|---|---|
| Stool analysis: Intestinal microbiome by sequencing 16S rRNA | Baseline, 4 weeks, 8 weeks, 6 months |
Countries
Germany
Outcome results
None listed