Brain Injuries
Conditions
Brief summary
To monitor changes in indicators of red cell damage such as extracellular hemoglobin, potassium (K-ABL), and lactate dehydrogenase (LD) post blast exposure.
Detailed description
Traumatic brain injury (TBI) causes significant morbidity and mortality, accompanied by high related costs. Recent hypotheses concerning the pathophysiology of TBI invoke Strain Shear Theory and Cavitation Theory. The invbestigators propose to test the importance of the latter by directing blast waves into containers that are either partially or completely filled with blood and measuring markers of lysis. These experiments are designed to better understand the demonstrated effectiveness of mild jugular compression according to the principle of the Queckenstedt Maneuver to reduce the likelihood of TBI by filling up the compliance of the cranial space. A device (C-Collar) is being developed by Q30 Labs, LLC (Q30), to accomplish this effect.
Interventions
OTHERblood draw
subjects will have blood drawn done. This blood will then be exposed to blasting with CO2 cartridge
Sponsors
Children's Hospital Medical Center, Cincinnati
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* • Normal healthy volunteer * Able to provide written consent * Must be 18 years or older
Exclusion criteria
* • Unable to provide written consent * Recent penetrating brain trauma (within 6 months) * Under the age of 18 years
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Lysis of blood cells | within 2 hours | measure the lysis of blood cells exposed to blast from CO2 cartridge |
Countries
United States
Outcome results
None listed