Age Problems, Insulin Resistance
Conditions
Brief summary
This study intends to examine the effect of a commercially available nutritional supplement, Beta-hydroxy-beta-methylbutyrate(HMB) on whole-body responses to a sugar load.
Detailed description
One change associated with human aging is a reduction in fitness, both in terms of how far or quickly a person can run/cycle/swim and also in how well their blood vessels work. Additionally a person's metabolic fitness decreases; this is how well the body copes with nutrition and is why, for example, older people have a higher risk of diseases like type 2 diabetes. Previous studies have shown that as people become less fit, they are at increased risk of suffering a complication whilst undergoing surgery. It has also been shown that measuring how fit someone is, is better at predicting the risk of a surgical complication than purely using a person's age alone. Lots of research has shown that exercise can potentially reverse some of the age-related declines in fitness, however most has used long sessions of continuous exercise over a long period of time. High-intensity interval training (HIT), whereby people cycle on an exercise bike very hard for a minute, followed by a short rest, repeated over the course of 15 minutes can rapidly improve a person's fitness. However not everyone will be able to, or indeed want to participate in exercise this strenuous; therefore this research seeks to explore whether other options, such as dietary supplements can improve aspects of fitness This study intends to examine the effect of giving a dietary supplement on the way a person's body handles the glucose (from carbohydrates/ sugars) in a meal. Previous work has shown that taking a beta-hydroxy beta-methyl butyrate (HMB) supplement may improve may improve a patient's response to glucose, however the evidence is not clear. HMB is a commercially available nutritional supplement providing a compound that the body produces each time protein is consumed, and is most commonly used by bodybuilders to help gain muscle.
Interventions
DIETARY_SUPPLEMENTBeta-Hydroxy-Beta-Methylbutyrate
OTHERPlacebo
Sponsors
University of Nottingham
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
MALE
Age
18 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy volunteers * Aged 18-35 or 65-85 * Male
Exclusion criteria
* Current participation in a formal exercise regime * A BMI \< 18 or \> 32 kg·m2 * Active cardiovascular disease: o uncontrolled hypertension (BP \> 160/100), angina, heart failure (class III/IV), Significant arrhythmia, right to left cardiac shunt, recent cardiac event * Taking beta-adrenergic blocking agents, * Cerebrovascular disease: o previous stroke, aneurysm (large vessel or intracranial), epilepsy * Respiratory disease including: o pulmonary hypertension, significant COPD, uncontrolled asthma, * Metabolic disease: o hyper and hypo parathyroidism, untreated hyper and hypothyroidism, Cushing's disease, type 1 or 2 diabetes * Active inflammatory bowel or renal disease * Malignancy * Clotting dysfunction * Significant musculoskeletal or neurological disorders * Family history of early (\<55y) death from cardiovascular disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Matsuda Index of insulin sensitivity | 180 minutes after a 75g oral glucose load | Assessed from arterialised venous blood samples |
| Cederholm index of insulin sensitivity | 180 minutes after a 75g oral glucose load | Assessed from arterialised venous blood samples |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Area-Under-Curve Glucose Concentration | 180 minutes after a 75g oral glucose load | Assessed from arterialised venous blood samples |
| Area-Under-Curve Insulin Concentration | 180 minutes after a 75g oral glucose load | Assessed from arterialised venous blood samples |
| Femoral Artery Blood flow | 15 minutes, 60 minutes and 120 minutes after a 75g oral glucose load | Assessed using duplex ultrasonography of the superficial femoral artery of the right leg |
Countries
United Kingdom
Outcome results
None listed