Intrathecal Clonidine Addiction for Combined Spinal Epidural Analgesia During Labor

Impact on Maternal and Fetal Wellbeing and on Labor Curve of Intrathecal Clonidine Addiction for Labor Analgesia. A Randomized Controlled Trial.

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03018171

Acronym

ICA

Enrollment

268

Registered

2017-01-11

Start date

2017-01-31

Completion date

2017-08-31

Last updated

2017-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Labor Pain

Keywords

clonidine, spinal injections

Brief summary

The study aims to evaluate the impact of the addition of 20 mcg of intrathecal clonidine in combined spinalepidural for labor analgesia on the local anesthetic consumption, on labor performance and on maternal fetal well-being.

Interventions

DRUGClonidine

Intrathecal clonidine addiction

DRUGSufentanil

Intrathecal

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 40 Years

Healthy volunteers

Inclusion criteria

* Written maternal informed consent * Singleton pregnancy * Gestational age ≥ 37 weeks, * ASA I * BMI \< 30 * fetus in cephalic presentation

Exclusion criteria

* Suspect or certainty of fetal malformation, * Presence of conditions such as preeclampsia, multiparity, preterm labor * History of adverse reaction to α-2 adrenergic agonists * Nicotine addiction * Chronic use of opioid

Design outcomes

Primary

Measure	Time frame
local anesthetic consumption reduction	8 months

Countries

Italy

Contacts

Primary ContactMaria Grazia Frigo, MD

mariagrazia.frigo@fbf-isola.it+39066837258

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026