Volumetric Study of Fat Resorption After Breast Lipofilling

LIPOFILLING IN BREAST SURGERY: VOLUMETRIC EVALUATION OF FAT RESORPTION AFTER WASHING WITH RINGER'S LACTATE

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03016663

Acronym

Lipofilling

Enrollment

Registered

2017-01-10

Start date

2015-09-30

Completion date

2016-12-31

Last updated

2017-01-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cosmetic Techniques, Mammaplasty

Brief summary

Prospective observational study to evaluate effects on washing to improve viability of fat grafts in breast lipofilling.

Interventions

PROCEDURETechnique of Breast Lipofilling

1. Identification of the donor site Procedure carried out in single sessions under GA. Abdominal site identified and outlined with a skin marker. 2. Fat Harvesting Berlin autologous lipotransplantation technique used according to the BEAULI protocol described by Ueberreiter et al. Infiltration solution -Klein'solution contains 1 cc of epinephrine (1:500,000) diluted in 500 cc of 0.001% lactate ringer solution (LRS). 3. Fat Processing After aspiration of nonviable components of the aspirate, fat graft washed using Lactate Ringer Solution for three times. The fat processing and washing were performed by the same assistant for all patients. 4. Fat Transfer (Injection) Fat is injected in small amounts as the needle is gradually withdrawn. Periglandular planes and intrapectoral planes are used. Intraparenchymal injection avoided.

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients with breast defect post breast surgery and unsatisfied. The first lipofilling procedure delayed for at least 9 months after the completion of radiotherapy. Patient on chemotherapy deferred until at least 6 month of last chemotherapy.

Exclusion criteria

* Patients are excluded if they experienced local recurrence or distant metastasis

Design outcomes

Primary

Measure	Time frame	Description
Measure fat graft resorption rate after washing with buffered lactate by volumeric MRI imaging	6 month after breast lipofilling	MRI Breast performed before the first lipofilling session, at 1st and 6th months after the lipofilling procedure. Volume measurement performed using OsiriX (v7.0.3, 64 bit , Pixmeo c)

Secondary

Measure	Time frame	Description
Confounding factors	6 month after breast lipofilling	To identify confounding factors that affect fat resorption rate in breast lipofilling To evaluate the fat resorption following breast lipofilling with volumetric MRI imaging

Countries

Malaysia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026