Knee Osteoarthritis
Conditions
Keywords
Biomarkers
Brief summary
It was previously proved an association of TGF-β1 and PDGF-BB with the pathogenesis of osteoarthritis (OA) by experiments of OA animal models. In this study, we aimed to determine whether serum concentrations of TGF-β1, PDGF-BB and CTX-1 were related to the knee OA. knee OA cases were collected from the first affiliated hospital of Shihezi university and healthy controls were recruited from the community. The severity of knee OA was defined as kellgren-lawrence (K-L) classification criteria.Serum levels of chemical biomarkers were compared between knee OA cases and controls or among K-L grade 2 to grade 4 groups. The serum concentrations of the TGF-β1, PDGF-BB and CTX-1 were determined by ELISA .
Interventions
RADIATIONx-ray images
Sponsors
Shihezi University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
38 Years to 78 Years
Healthy volunteers
Yes
Inclusion criteria
* OA diagnosis was on the basis of the diagnosis and treatment guideline of the American Academy of Orthopedic Surgeons
Exclusion criteria
Participants who met the following criteria were excluded： * the knee OA concomitant with hip OA, * suppurative and rheumatoid arthritis, * gout patients, * patients who underwent knee arthroscopy surgery within 6 months, * bilateral or unilateral knee replacements, * the knee joint trauma patients, * histories of glucocorticoid and/or sterol hormones.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum levels of Transforming Growth Factor Beta1 (TGF-β1) and Platelet Derived Growth Factor BB (PDGF-BB) may be novel biomarkers in knee osteoarthritis | 3 years |
Outcome results
None listed