Heterotopic Gastric Mucosa of the Proximal Esophagus
Conditions
Keywords
heterotopic gastric mucosa, cervical inlet patch, narrow band imaging, endoscopy
Brief summary
The aim of the study is to determine whether Narrow Band Imaging(NBI) should be routinely used during esophagus inspection at diagnostic gastroscopy.
Detailed description
Heterotopic gastric mucosa, also called inlet patch, is area of ectopic gastric mucosa with common location at proximal part of esophagus. Because of the location, lesions are likely to be missed during routine gastroscopy. The clinical significance of inlet patches remains unknown, however they may be symptomatic and may cause morphologic changes such as strictures, ulcers, webs, stenoses or even adenocarcinomas. Moreover inlet patches may be correlated with reflux symptoms up to 73,1%. Several studies were conducted to determine whether NBI improves detection of cervical inlet patches, some of them were also prospective studies, however no randomized study was conducted.
Interventions
DEVICEEsophagus inspection in Narrow Band imaging.
During the endoscope withdrawal after cardia examination NBI will be used for esophagus inspection.
DEVICEStandard High definition endoscopy.
Whole procedure will be performed in standard High definition endoscopy.
DEVICEEsophagus inspection in Narrow Band imaging and increased care.
During the endoscope withdrawal after cardia examination NBI will be used for esophagus inspection and with increased care of cervical inlet patches detection.
DEVICEStandard High definition endoscopy and increased care.
Whole procedure will be performed in standard High definition endoscopy with increased care of cervical inlet patches detection.
Sponsors
Tomasz Romańczyk
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Referral for diagnostic gastroscopy * Ability to undergo diagnostic gastroscopy * Provided written informed consent
Exclusion criteria
* Age \<18 * Prisoners * Pregnancy * Gastroscopy with treatment procedure * Inability to provide informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Detection of heterotopic gastric mucosa in the proximal esophagus | Day 1 |
Secondary
| Measure | Time frame |
|---|---|
| Detection of other upper gastrointestinal lesions | Day 1 |
| Correlation of throat and esophageal reflux symptoms with cervical inlet patches | Day 1 |
| Rate of cervical inlet patches verified with NBI in endoscopies performed in standard white light endoscopy | Day 1 |
| Total and esophagus inspection time | Day 1 |
| Correlation of subject's subjective purpose of gastroscopy and cervical inlet patch occurrence | Day 1 |
Countries
Poland
Outcome results
None listed