Inherited Susceptible Genes Among Epithelial Ovarian Cancer

Cohort Study on Characters and Distribution of Inherited Susceptible Genes Among Epithelial Ovarian Cancer Patients and Their Relatives in the North of China

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03015376

Enrollment

1000

Registered

2017-01-10

Start date

2017-01-31

Completion date

2019-01-31

Last updated

2018-11-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hereditary Breast and Ovarian Cancer Syndrome, Ovarian Neoplasm Epithelial

Keywords

epithelial ovarian cancer, Hereditary Breast and Ovarian Cancer Syndrome, next-generation sequencing, High-Throughput Nucleotide Sequencing

Brief summary

Purpose: To investigate the prevalence of the germline mutations in the BRCA 1/2 and mismatch repair genes in patients with epithelial ovarian cancer (EOC) and their relatives, and related somatic mutations in tumor tissues in the northern part of china. Patients and methods: A multicenter prospective study will be hold in the northern part of china form 2017. About 1000 female patients with epithelial ovarian cancer and their ralatives will be tested for germline mutations in the BRCA 1/2 and mismatch repair genes and related somatic mutations in tumor tissues, regardless of the family history. Study type: Observational Official title: Prevalence study of germline mutations in susceptibility ovarian cancer genes in patients with epithelial ovarian cancer and somatic mutations in their tumor tissures in the northern part of china. Enrollment: 1000

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

1. epithelial ovarian cancer and their relatves 2. living in the north of Huaihe River in China 3. being Han Chinese

Exclusion criteria

1. non-epithelial ovarian cancer 2. without specific pathological diagnosis 3. non-Han Chinese

Design outcomes

Primary

Measure	Time frame
herited gene mutations susceptible to epithelial ovarian cancer in patients and their relatives	two years

Countries

China

Contacts

Primary ContactWu Ming, MD

drwuming@sina.com+86-13801224549

Backup ContactLi Lei, MD

lileigh@163.com+86-13911988831

Outcome results