Anesthetics, Inhalation
Conditions
Keywords
blood sevoflurane concentration, blood desflurane concentration, one lung ventilation
Brief summary
16 patients with American Society of AnesthesioIogy (ASA) physical status I-III will recruited to this study. Patients will divided to the 2 groups. %1.5 Sevoflurane will apply in Group S and %6 Desflurane will apply in Group D. Each groups will divide 2 subgroups. Two lung ventilation will be performed to Group Sa and Group Da, one lung ventilation will be performed to Group Sb and Group Db. At the time point 40.minutes first blood sample will given from patients. Blood sample will be taken at intervals of 10 minutes from groups of two lung ventilation. In groups of one lung ventilation, blood samples will be taken at the time interval of 10 minutes after one lung ventilation started. All blood samples will be assess in Gas Chromatography.
Detailed description
Investigator aimed to assess blood level of sevoflurane and desflurane during two lung ventilation and one lung ventilation. The investigators will use Gas Chromatography for define drugs levels. 16 patients with ASA I-III patients who undergo thoracotomy and abdominal surgery will be recruited to this study. Patients will divided in to the 2 groups. %1.5 Sevoflurane will apply in Group S and %6 Desflurane will apply in Group D during anesthesia maintenance. Each groups will divide 2 subgroups which are one lung ventilation groups and two lung ventilation groups. Two lung ventilation will be performed to Group Sa and Group Da, one lung ventilation will be performed to Group Sb and Group Db. Sequential blood samples will be taken from both arterial and central venous canula at the same time point. First blood samples will be taken at 40. minutes of anesthesia. Sequential samples will be taken at interval of 10 minutes during two lung ventilation. In one lung ventilation second blood samples will be taken at the 10. minutes of one lung ventilation. After than at the interval of 10 minutes, collection of blood samples both arterial and central venous will be continue. All collection will assess with gas chromatography.
Interventions
DRUGSevoflurane
Measurement of blood desflurane level during one lung ventilation
DRUGDesflurane
Measurement of blood desflurane level during one lung ventilation
Sponsors
Cukurova University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
25 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
ASA I-II patients * Who undergo thoracotomy or abdominal surgery
Exclusion criteria
* ASA IV and up patients * Patients who taken inotropic agent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measurement of blood levels of Sevoflurane and Desflurane | from 40th minute to the end of the operation | Data collections will be ensured from arterial and venous blood sample and than samples will be assessed with gas chromatography and blood sevoflurane and desflurane level will be measured. Blood samples will take every 10 minutes. Only blood levels of sevoflurane and desflurane will be assessed. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| determine of ventilation-perfusion mismatch with p(A-a)O2 | from 40th minute to the end of the one lung ventilation | During one lung ventilation, p(a-A)O2 will be assessed with arterial blood analyses |
Countries
Turkey (Türkiye)
Outcome results
None listed