Chronic Obstructive Pulmonary Disease
Conditions
Keywords
COPD, CYP1A2, Theophylline
Brief summary
The aim of this study is to determine whether common CYP1A2 gene polymorphisms effect metabolism of theophylline in Han and Uygur Patients with chronic obstructive pulmonary disease patients.
Interventions
DRUGTheophylline
After oral theophylline 200mg per day for one week, blood sample will be collected for determining plasma concentrations of theophylline and it's metabolites and the genotypes of CYP1A2
Sponsors
Southern Medical University, China
XiaoGuang Zou
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Aged 18-75 years,Weight 40-80kg COPD patients, male or female; regularly visiting our hospital; taking a sustained-release preparation of theophylline continuously for at least 2 weeks
Exclusion criteria
* Patients with renal or hepatic dysfunction; Patients with congestive heart failure; Patients with hypothyroidism or hyperthyroidism; Patients currently taking drugs likely to effect theophylline metabolism or who had taken such drugs in the preceding week; Patients with extreme obesity Patients with very severe Chronic Obstructive Pulmonary Disease(COPD)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Plasma concentrations of theophylline | one week | Blood samples will be taken after receiving oral theophylline |
Countries
China
Outcome results
None listed