Prostate Cancer
Conditions
Brief summary
The main objective of the study is to determine the intra-prostatic concentration of sexual steroids when castration resistance appears in castration-resistant prostate cancer patients compared to patients naif of hormonal treatment
Interventions
BIOLOGICALintra-prostatic concentration of sexual steroids
PROCEDURETrans-rectal biopsy
Sponsors
Hopital Foch
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* group 1: patients with a locally advanced prostate cancer naif of any hormonal treatment * group 2: Patients with a castration-resistant prostate cancer resisting defined by a biological progression * group 2a: without radiotherapy * group 2b: with radiotherapy * Affiliated to a social security scheme * Having given a written consent.
Exclusion criteria
* Patient unable to supply a written consent (patient not understanding French, under guardianship patient). * neuro-endocrine form or sarcomatoid form prostate cancer
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| intra-prostatic concentration of sexual steroids | 2 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Androgen receptor RNA expression level | 2 weeks |
| Steroid 5-alphareductase immuno-histochemical expression level | 2 weeks |
| Androgen receptor immuno-histochemical expression level | 2 weeks |
| Steroid aromatase immuno-histochemical expression level | 2 weeks |
| Steroid aromatase RNA expression level | 2 weeks |
| Steroid 5-alphareductase RNA expression level | 2 weeks |
Countries
France
Outcome results
None listed