Metabolic Profiling of Type 1 Diabetes Mellitus in Children and Adolescents

Metabolic Profiling of Type 1 Diabetes Mellitus in Children and Adolescents: a Case-control Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03014908

Acronym

T1DM

Enrollment

Registered

2017-01-09

Start date

2014-01-31

Completion date

2014-12-31

Last updated

2017-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type1diabetes

Keywords

Type 1 diabetes, 1H-NMR spectroscopy, Metabolomics, Pediatrics

Brief summary

The aim of this study was to look for discriminating variation in the concentrations of small-molecule metabolites in the plasma of T1DM children compared with non-diabetic matched controls using proton nuclear magnetic resonance (1H-NMR)-based metabolomics.

Detailed description

Type 1 diabetes mellitus (T1DM) is one of the most common pediatric diseases and its incidence is rising in many countries. Recently, it has been shown that metabolites other than glucose play an important role in insulin deficiency and the development of diabetes. The aim of this study was to look for discriminating variation in the concentrations of small-molecule metabolites in the plasma of T1DM children compared with non-diabetic matched controls using proton nuclear magnetic resonance (1H-NMR)-based metabolomics. This cross-sectional study was set-up to examine the metabolic profile in fasting plasma samples from 7 T1DM children and 7 non-diabetic controls aged 8 to 18 years, and matched for gender, age and BMI. The obtained plasma 1H-NMR spectra were rationally divided into 110 integration regions, representing the metabolic phenotype. These integration regions reflect the relative metabolite concentrations and were used as statistical variables to construct (train) a classification model in discriminating between T1DM patients and controls.

Interventions

OTHERBlood sampling

Determine the metabolic phenotype of blood plasma by proton-NMR spectroscopy

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

8 Years to 18 Years

Healthy volunteers

Yes

Inclusion criteria

* aged between 8 and 18 * normal-weight according to the International Obesity Task Force (IOTF) BMI criteria * fasted for at least 8 hours.

Exclusion criteria

* lipid-lowering drugs or other medication

Design outcomes

Primary

Measure	Time frame	Description
Metabolic phenotype of type 1 diabetes mellitus	10 months	Significant metabolic changes in blood plasma of type 1 diabetic patients compared with control subjects

Countries

Belgium

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 9, 2026