Sperm DNA Damage in β-thalassemia Major: Is There a Role for Antioxidants?

Status

UNKNOWN

Phases

Phase 1Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03014882

Enrollment

Registered

2017-01-09

Start date

2015-02-28

Completion date

2017-12-31

Last updated

2017-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

DNA Damage, Endocrine Disease, Fertility Decreased Male

Brief summary

Accumulation of iron in patients with beta thalassemia major causes free radical formation which leads to damage of biological membranes. Sperm DNA damage may result from these generated antioxidants. We aimed at investigating the current DNA damage in the sperms of adult patients with beta thalassemia major and the effect generated by giving antioxidant treatment for 6 months.

Interventions

DRUGL-Carnitine and N-acetyl cysteine

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

MALE

Age

16 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Pubertal patients with beta thalassemia major

Exclusion criteria

* Associated endcrinopathy

Design outcomes

Primary

Measure	Time frame
DNA fragmentation index	6 months

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026