Rehabilitation, Working Memory
Conditions
Brief summary
This study aims to conduct a contrast study on the characteristics of functional and structural connectivity of neural networks of working memory in patients with acquired brain injury versus normal controls, using resting-state functional connectivity magnetic resonance imaging, task-specific functional magnetic resonance imaging and diffusion tensor imaging, combined with cognitive behavioral examinations. Another purpose is to reveal the characteristics of dynamic change of neural networks of working memory pre- and post-intervention in patients with working memory dysfunction.
Interventions
BEHAVIORALWorking memory training
Sponsors
China Rehabilitation Research Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Right handedness * Diagnosis of traumatic brain injury or stroke * Course of disease within one year * The score of MoCA test \> 24 * Able to understand instructions
Exclusion criteria
* Aphasia, unilateral spatial neglect, agnosia, apraxia * Hearing impairment or visual impairment * History of taking psychiatric drugs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Training-induced brain activations during working memory tasks in fMRI | six weeks | Training-induced increased and decreased brain activations (Number of voxels) during n-back verbal WM task compared to the pre-training baseline |
Secondary
| Measure | Time frame |
|---|---|
| The fluid intelligence measured by Raven's Standard Progressive Matrices (RSPM) test | six weeks |
| Attention ability assessed by Stroop color-word test | six weeks |
Countries
China
Contacts
Primary ContactXiaoping Yun, MD
Outcome results
None listed